A Boeing 737 MAX 8 carrying 149 passengers and eight crew members, took off at 08:38am (05:38 GMT) in Ethiopia and lost contact with air traffic controllers six minutes later.
It crashed near Bishoftu, southeast of the Ethiopian capital, Ethiopian Airlines said in a statement.
The plane delivered to the airline in November last year was in good condition. The pilot who had been working for the carrier since 2010 sent out a distress call shortly after take-off and was given clearance to return.
The airline’s CEO Tewolde Gebremariam visited the scene of the crash and confirmed that no one had survived.